Open AccessSynthesis and characterization of 5‐aminosalicylic acid based poly(anhydride‐esters) by solution polymerization
Author(s) -
Kim Youngmi,
Uhrich Kathryn E.
Publication year - 2010
Publication title -
journal of polymer science part a: polymer chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.768
H-Index - 152
eISSN - 1099-0518
pISSN - 0887-624X
DOI - 10.1002/pola.24381
Subject(s) - polymerization , polymer , polymer chemistry , solubility , alkyl , chemistry , amine gas treating , organic chemistry , materials science
Poly(anhydride‐esters) based on 5‐aminosalicylic acid (5‐ASA) were synthesized via solution polymerization. This polymerization method produced polymers with higher molecular weights and better solubility in organic solvents, relative to polymers produced by melt condensation polymerization. Three synthetic steps were required to introduce 5‐ASA into polymers via biodegradable bonds such as esters. By changing the alkyl lengths of either the amine protecting group or linkage between 5‐ASA units, a range of 5‐ASA‐based polymers with varying glass transition temperatures, molecular weights, and solubilities in low‐boiling organic solvents were prepared.