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Factors that impact on women's decision‐making around prenatal genomic tests: An international discrete choice survey
Author(s) -
Buchanan James,
Hill Melissa,
Vass Caroline M.,
Hammond Jennifer,
Riedijk Sam,
Klapwijk Jasmijn E.,
Harding Eleanor,
Lou Stina,
Vogel Ida,
Hui Lisa,
IngvoldstadMalmgren Charlotta,
Soller Maria Johansson,
Ormond Kelly E.,
Choolani Mahesh,
Zheng Qian,
Chitty Lyn S.,
Lewis Celine
Publication year - 2022
Publication title -
prenatal diagnosis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.956
H-Index - 97
eISSN - 1097-0223
pISSN - 0197-3851
DOI - 10.1002/pd.6159
Subject(s) - test (biology) , logistic regression , medicine , demography , china , logit , statistics , geography , mathematics , biology , paleontology , archaeology , sociology
Objective We conducted a survey‐based discrete‐choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries. Methods Five test attributes were identified as being important for decision‐making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis. Results Surveys from 1239 women (Australia: n = 178; China: n = 179; Denmark: n = 88; Netherlands: n = 177; Singapore: n = 90; Sweden: n = 178; UK: n = 174; USA: n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield ( p < 0.01). Women preferred tests with short turnaround times ( p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country‐specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs. Conclusion Most women want maximum information from prenatal genomic tests, but our findings highlight country‐based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable.