Open AccessUse of In Vivo Real‐Time Optical Imaging for Esophageal Neoplasia
Author(s) -
Vila Peter M.,
Thekkek Nadhi,
RichardsKortum Rebecca,
Anandasabapathy Sharmila
Publication year - 2011
Publication title -
mount sinai journal of medicine: a journal of translational and personalized medicine
Language(s) - English
Resource type - Journals
eISSN - 1931-7581
pISSN - 0027-2507
DOI - 10.1002/msj.20304
Subject(s) - medicine , esophageal adenocarcinoma , esophagus , optical imaging , medical imaging , imaging technique , adenocarcinoma , radiology , pathology , barrett's esophagus , esophageal disease , surgery , cancer , physics , optics
Esophageal adenocarcinoma carries a poor prognosis, as it typically presents at a late stage. Thus, a major research priority is the development of novel diagnostic‐imaging strategies that can detect neoplastic lesions earlier and more accurately than current techniques. Advances in optical imaging allow clinicians to obtain real‐time histopathologic information with instant visualization of cellular architecture and the potential to identify neoplastic tissue. The various endoscopic imaging modalities for esophageal neoplasia can be grouped into 2 major categories: (1) wide‐field imaging, a comparatively lower‐resolution view for imaging larger surface areas, and (2) high‐resolution imaging, which allows individual cells to be visualized. This review will provide an overview of the various forms of real‐time optical imaging in the diagnosis and management of Barrett's esophagus and esophageal adenocarcinoma. Mt Sinai J Med 78:894–904, 2011. © 2011 Mount Sinai School of Medicine