A year of unprecedented progress in Down syndrome basic research

The years 2006 and 2007 saw the publication of three new and different approaches to prevention or amelioration of Down syndrome effects on the brain and cognition. We describe the animal model systems that were critical to this progress, review these independent breakthrough studies, and discuss the implications for therapeutic approaches suggested by each. © 2007 Wiley‐Liss, Inc. MRDD Research Reviews 2007;13:215–220.