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Restriction of Dietary Advanced Glycation End Products Induces a Differential Plasma Metabolome and Lipidome Profile
Author(s) -
Berdún Rebeca,
Jové Mariona,
Sol Joaquim,
Cai Weijing,
He John C.,
RodriguezMortera Reyna,
MartinGarí Meritxell,
Pamplona Reinald,
Uribarri Jaime,
PorteroOtin Manuel
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202000499
Subject(s) - metabolome , lipidome , lipidomics , glycation , metabolomics , glycerophospholipid , chemistry , sphingolipid , metabolism , lipid metabolism , endocrinology , medicine , diabetes mellitus , biochemistry , biology , chromatography , phospholipid , membrane
Scope Diets with low content in advanced glycation end products (AGEs) lead to beneficial properties in highly prevalent age‐related diseases. To shed light on the mechanisms behind, the changes induced by a low AGE dietary intervention in the circulating metabolome are analyzed. Methods and Results To this end, 20 non‐diabetic patients undergoing peritoneal dialysis are randomized to continue their usual diet or to one with a low content of AGEs for 1 month. Then, plasmatic metabolome and lipidomes are analyzed by liquid‐chromatography coupled to mass spectrometry. The levels of defined AGE structures are also quantified by ELISA and by mass‐spectrometry. The results show that the low AGE diet impinged significant changes in circulating metabolomes (166 molecules) and lipidomes (91 lipids). Metabolic targets of low‐AGE intake include sphingolipid, ether‐lipids, and glycerophospholipid metabolism. Further, it reproduces some of the plasma characteristics of healthy aging. Conclusion The finding of common pathways induced by low‐AGE diets with previous metabolic traits implicated in aging, insulin resistance, and obesity suggest the usefulness of the chosen approach and supports the potential extension of this study to other populations.