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Rapid Eye Movement Sleep Behavior Disorder: Abnormal Cardiac Image and Progressive Abnormal Metabolic Brain Pattern
Author(s) -
Janzen Annette,
Kogan Rosalie V.,
Meles Sanne K.,
Sittig Elisabeth,
Renken Remco J.,
Geibl Fanni F.,
Booij Jan,
Stormezand Gilles,
Luster Markus,
Mayer Geert,
Leenders Klaus L.,
Oertel Wolfgang H.
Publication year - 2022
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28859
Subject(s) - pathological , psychology , positron emission tomography , rem sleep behavior disorder , hyposmia , central nervous system disease , movement disorders , parkinson's disease , rapid eye movement sleep , nuclear medicine , medicine , pathology , cardiology , neuroscience , eye movement , disease , covid-19 , infectious disease (medical specialty)
Background Isolated rapid eye movement sleep behavior disorder (iRBD) is prodromal for α‐synucleinopathies. Objective The aim of this study was to determine whether pathological cardiac [ 123 I]meta‐iodobenzylguanidine scintigraphy ([ 123 I]MIBG) is associated with progression of [ 18 F]fluorodeoxyglucose‐positron emission tomography–based Parkinson's disease (PD)‐related brain pattern (PDRP) expression in iRBD. Methods Seventeen subjects with iRBD underwent [ 18 F]fluorodeoxyglucose‐positron emission tomography brain imaging twice ~3.6 years apart. In addition, [ 123 I]MIBG and [ 123 I] N ‐ω‐fluoropropyl‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)nortropane single‐photon emission computed tomography ([ 123 I]FP‐CIT‐SPECT) at baseline were performed. Olfactory, cognitive, and motor functions were tested annually. Results Twelve of 17 subjects had pathological [ 123 I]MIBG. At baseline, 6 of 12 of these expressed the PDRP (suprathreshold PDRP z score). At follow‐up, 12 of 17 subjects had suprathreshold PDRP z scores, associated with pathological [ 123 I]MIBG in 92% and with pathological [ 123 I]FP‐CIT‐SPECT in 75%. Subjects with pathological [ 123 I]MIBG had higher PDRP z score change per year ( P = 0.027). Three subjects phenoconverted to PD; all had pathological [ 123 I]MIBG and [ 123 I]FP‐CIT‐SPECT, suprathreshold baseline PDRP z scores, and hyposmia. Conclusions Pathological [ 123 I]MIBG was associated with progressive and suprathreshold PDRP z scores at follow‐up. Abnormal [ 123 I]MIBG likely identifies iRBD as prodromal PD earlier than pathological [ 123 I]FP‐CIT‐SPECT. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society