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International Multicenter Analysis of Brain Structure Across Clinical Stages of Parkinson's Disease
Author(s) -
Laansma Max A.,
Bright Joanna K.,
AlBachari Sarah,
Anderson Tim J.,
Ard Tyler,
Assogna Francesca,
Baquero Katherine A.,
Berendse Henk W.,
Blair Jamie,
Cendes Fernando,
DalrympleAlford John C.,
Bie Rob M.A.,
Debove Ines,
Dirkx Michiel F.,
Druzgal Jason,
Emsley Hedley C.A.,
Garraux Gäetan,
Guimarães Rachel P.,
Gutman Boris A.,
Helmich Rick C.,
Klein Johannes C.,
Mackay Clare E.,
McMillan Corey T.,
Melzer Tracy R.,
Parkes Laura M.,
Piras Fabrizio,
Pitcher Toni L.,
Poston Kathleen L.,
Rango Mario,
Ribeiro Letícia F.,
Rocha Cristiane S.,
Rummel Christian,
Santos Lucas S.R.,
Schmidt Reinhold,
Schwingenschuh Petra,
Spalletta Gianfranco,
Squarcina Letizia,
Heuvel Odile A.,
Vriend Chris,
Wang JiunJie,
Weintraub Daniel,
Wiest Roland,
Yasuda Clarissa L.,
Jahanshad Neda,
Thompson Paul M.,
Werf Ysbrand D.
Publication year - 2021
Publication title -
movement disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.352
H-Index - 198
eISSN - 1531-8257
pISSN - 0885-3185
DOI - 10.1002/mds.28706
Subject(s) - putamen , neuroimaging , thalamus , amygdala , neuroscience , parkinson's disease , psychology , medicine , cortex (anatomy) , disease , pathology
Background Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective Using a multicenter approach and harmonized analysis methods, we aimed to shed light on Parkinson's disease stage‐specific profiles of pathology, as suggested by in vivo neuroimaging. Methods Individual brain MRI and clinical data from 2357 Parkinson's disease patients and 1182 healthy controls were collected from 19 sources. We analyzed regional cortical thickness, cortical surface area, and subcortical volume using mixed‐effects models. Patients grouped according to Hoehn and Yahr stage were compared with age‐ and sex‐matched controls. Within the patient sample, we investigated associations with Montreal Cognitive Assessment score. Results Overall, patients showed a thinner cortex in 38 of 68 regions compared with controls ( d max = −0.20, d min = −0.09). The bilateral putamen ( d left = −0.14, d right = −0.14) and left amygdala ( d = −0.13) were smaller in patients, whereas the left thalamus was larger ( d = 0.13). Analysis of staging demonstrated an initial presentation of thinner occipital, parietal, and temporal cortices, extending toward rostrally located cortical regions with increased disease severity. From stage 2 and onward, the bilateral putamen and amygdala were consistently smaller with larger differences denoting each increment. Poorer cognition was associated with widespread cortical thinning and lower volumes of core limbic structures. Conclusions Our findings offer robust and novel imaging signatures that are generally incremental across but in certain regions specific to disease stages. Our findings highlight the importance of adequately powered multicenter collaborations. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society