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Enzymatic Synthesis of Polyesters and Their Bioapplications: Recent Advances and Perspectives
Author(s) -
Hevilla Víctor,
Sonseca Agueda,
Echeverría Coro,
MuñozBonilla Alexandra,
FernándezGarcía Marta
Publication year - 2021
Publication title -
macromolecular bioscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.924
H-Index - 105
eISSN - 1616-5195
pISSN - 1616-5187
DOI - 10.1002/mabi.202100156
Subject(s) - polyester , condensation polymer , polymer , polymerization , chemistry , drug delivery , nanotechnology , combinatorial chemistry , organic chemistry , materials science , polymer science
This article reviews the most important advances in the enzymatic synthesis of polyesters. In first place, the different processes of polyester enzymatic synthesis, i.e., polycondensation, ring opening, and chemoenzymatic polymerizations, and the key parameters affecting these reactions, such as enzyme, concentration, solvent, or temperature, are analyzed. Then, the latest articles on the preparation of polyesters either by direct synthesis or via modification are commented. Finally, the main bioapplications of enzymatically obtained polyesters, i.e., antimicrobial, drug delivery, or tissue engineering, are described. It is intended to point out the great advantages that enzymatic polymerization present to obtain polymers and the disadvantages found to develop applied materials.