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Determination of vacuum ultraviolet detector response factors by hyphenation with two‐dimensional comprehensive gas chromatography with flame ionization detection
Author(s) -
Lelevic Aleksandra,
Geantet Christophe,
Lorentz Chantal,
Moreaud Maxime,
Souchon Vincent
Publication year - 2021
Publication title -
journal of separation science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.72
H-Index - 102
eISSN - 1615-9314
pISSN - 1615-9306
DOI - 10.1002/jssc.202100459
Subject(s) - ultraviolet , chemistry , flame ionization detector , gas chromatography , analytical chemistry (journal) , ionization , detector , chromatography , optoelectronics , materials science , optics , organic chemistry , physics , ion
Two‐dimensional comprehensive gas chromatography is an established technique, employed for the characterization of complex samples. Broadband vacuum ultraviolet absorption spectroscopy detection has recently attracted a lot of attention as it is a universal detection technique characterized by good selectivity but also ease of use and amenability to coupling with two‐dimensional comprehensive gas chromatography. Vacuum ultraviolet spectroscopy is particularly interesting due to the possibility of performing spectral decomposition for species that coelute in gas chromatography analysis. This detector has quantitative capabilities, however not all species absorb vacuum ultraviolet radiation the same. Unfortunately, vacuum ultraviolet relative response factors for compounds are not always available. Methods to rapidly measure vacuum ultraviolet relative response factors and generate a large database that would allow calibration free quantitative analysis of complex mixtures are therefore of great interest. In this work, a universal methodology that permits rapid measurement of vacuum ultraviolet relative response factors is reported. It involves flow modulated two‐dimensional comprehensive gas chromatography with dual vacuum ultraviolet and flame ionization detection. In this set‐up, flame ionization detection is employed as a quantitative reference allowing to scale vacuum ultraviolet responses of investigated compounds. This approach was validated by flow measurements and by comparing relative response factors obtained for model compounds with literature data.