Open AccessLarge‐scale production of extracellular vesicles: Report on the “massivEVs” ISEV workshop
Author(s) -
Paolini Lucia,
MonguióTortajada Marta,
Costa Marta,
Antenucci Fabio,
Barilani Mario,
ClosSansalvador Marta,
Andrade André Cronemberger,
Driedonks Tom A. P.,
Giancaterino Sara,
Kronstadt Stephanie M.,
Mizenko Rachel R.,
Nawaz Muhammad,
Osteikoetxea Xabier,
Pereira Carla,
Shrivastava Surya,
Boysen Anders Toftegaard,
Wakker Simonides Immanuel,
Herwijnen Martijn J. C.,
Wang Xiaoqin,
Watson Dionysios C.,
Gimona Mario,
KaparakisLiaskos Maria,
Konstantinov Konstantin,
Lim Sai Kiang,
MeisnerKober Nicole,
Stork Michiel,
Nejsum Peter,
Radeghieri Annalisa,
Rohde Eva,
Touzet Nicolas,
Wauben Marca H. M.,
Witwer Kenneth W.,
Bongiovanni Antonella,
Bergese Paolo
Publication year - 2022
Publication title -
journal of extracellular biology
Language(s) - English
Resource type - Journals
ISSN - 2768-2811
DOI - 10.1002/jex2.63
Subject(s) - extracellular vesicles , extracellular vesicle , scale (ratio) , nanotechnology , production (economics) , computer science , chemistry , biology , physics , materials science , microvesicles , microbiology and biotechnology , biochemistry , macroeconomics , economics , microrna , quantum mechanics , gene
Extracellular vesicles (EVs) large‐scale production is a crucial point for the translation of EVs from discovery to application of EV‐based products. In October 2021, the International Society for Extracellular Vesicles (ISEV), along with support by the FET‐OPEN projects, “The Extracellular Vesicle Foundry” (evFOUNDRY) and “Extracellular vesicles from a natural source for tailor‐made nanomaterials” (VES4US), organized a workshop entitled “massivEVs” to discuss the potential challenges for translation of EV‐based products. This report gives an overview of the topics discussed during “massivEVs”, the most important points raised, and the points of consensus reached after discussion among academia and industry representatives. Overall, the review of the existing EV manufacturing, upscaling challenges and directions for their resolution highlighted in the workshop painted an optimistic future for the expanding EV field.