Open AccessHandgrip strength and all‐cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study
Author(s) -
EstebanCornejo Irene,
Ho Frederick K.,
PetermannRocha Fanny,
Lyall Donald M.,
MartinezGomez David,
CabanasSánchez Verónica,
Ortega Francisco B.,
Hillman Charles H.,
Gill Jason M.R.,
Quinn Terence J.,
Sattar Naveed,
Pell Jill P.,
Gray Stuart R.,
CelisMorales Carlos
Publication year - 2022
Publication title -
journal of cachexia, sarcopenia and muscle
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.803
H-Index - 66
eISSN - 2190-6009
pISSN - 2190-5991
DOI - 10.1002/jcsm.12857
Subject(s) - dementia , grip strength , medicine , quartile , incidence (geometry) , confounding , cohort study , confidence interval , prospective cohort study , cohort , gerontology , physical therapy , disease , physics , optics
Abstract Background This study aimed to investigate the associations of grip strength with incidence and mortality from dementia and whether these associations differ by sociodemographic and lifestyle factors. Methods A total of 466 788 participants of the UK Biobank (median age 56.5 years, 54.5% women). The outcome was all‐cause dementia incidence and mortality and the exposure was grip strength. Grip strength was assessed using a Jamar J00105 hydraulic hand dynamometer. Results Excluding the first 2 years of follow‐up (landmark analysis), mean follow‐up was 9.1 years (inter‐quartile range: 8.3; 9.7) for incidence and 9.3 (inter‐quartile range: 8.7; 10.0) for mortality. During this time, 4087 participants developed dementia, and 1309 died from it. Lower grip strength was associated with a higher risk of dementia incidence and mortality independent of major confounding factors ( P < 0.001). Individuals in the lowest quintile of grip strength had 72% [95% confidence interval (CI): 1.55; 1.92] higher incident dementia risk and 87% [95% CI: 1.55; 2.26] higher risk of dementia mortality compared with those in the highest quintile. Our PAF analyses indicate that 30.1% of dementia cases and 32.3% of dementia deaths are attributable to having low grip strength. The association between grip strength and dementia outcomes did not differ by lifestyle or sociodemographic factors. Conclusions Lower grip strength was associated with a higher risk of all‐cause dementia incidence and mortality, independently of important confounding factors.