Continuous antibiotic fermentation—design of a 20 litre, single‐stage pilot plant and trials with two contrasting processes | Zendy

Bartlett M. C. | Zendy; Gerhardt Philipp | Zendy

Open Access

Continuous antibiotic fermentation—design of a 20 litre, single‐stage pilot plant and trials with two contrasting processes

Author(s) -

Bartlett M. C.,

Gerhardt Philipp

Publication year - 1959

Publication title -

journal of biochemical and microbiological technology and engineering

Language(s) - English

Resource type - Journals

eISSN - 1547-173X

pISSN - 0368-1467

DOI - 10.1002/jbmte.390010404

Subject(s) - fermentation , penicillin , pilot plant , dilution , antibiotics , volume (thermodynamics) , chloramphenicol , liter , stage (stratigraphy) , pulp and paper industry , chemistry , waste management , medicine , food science , biology , microbiology and biotechnology , engineering , thermodynamics , physics , paleontology

The feasibility of producing antibiotics by single‐stage continuous fermentation was explored by means of a specially designed pilot plant. Both the chloramphenicol and penicillin processes appeared adaptable to such an operation. At dilution rates of 1·0 and 0·5 volume changes per day respectively, yields of from ¼ to ½ of the maxima obtained in batch operation were maintained in the steady‐state for more than 2 weeks.

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