Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and  N ‐sulfate content | Zendy

Sederel L. C. | Zendy; van Der Does L. | Zendy; van Duijl J. F. | Zendy; Beugeling T. | Zendy; Bantjes A. | Zendy

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Anticoagulant activity of a synthetic heparinoid in relation to molecular weight and N ‐sulfate content

Author(s) -

Sederel L. C.,

van Der Does L.,

van Duijl J. F.,

Beugeling T.,

Bantjes A.

Publication year - 1981

Publication title -

journal of biomedical materials research

Language(s) - English

Resource type - Journals

eISSN - 1097-4636

pISSN - 0021-9304

DOI - 10.1002/jbm.820150606

Subject(s) - heparinoid , polyelectrolyte , sulfate , polymer chemistry , isocyanate , chemistry , carboxylate , heparin , adduct , polymer , organic chemistry , biochemistry , polyurethane

Addition of chlorosulfonyl isocyanate to CC bonds in cis ‐1,4‐polyisoprene and reaction of the adduct with NaOH resulted in the formation of a water‐soluble polyelectrolyte with N ‐sulfate and carboxylate groups. The polyelectrolyte showed anticoagulant activity and it was found, just as with heparin, that the activity was related to molecular weight and N ‐sulfate content.

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