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Counteracting Enantiospecific Behavior of Tailor‐Made Additives During Chiral Symmetry Breaking: Growth Inhibition versus Solid‐Solution Formation
Author(s) -
Baglai Iaroslav,
Dongen Sjoerd W.,
Leeman Michel,
Kellogg Richard M.,
Kaptein Bernard,
Noorduin Willem L.
Publication year - 2021
Publication title -
israel journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.908
H-Index - 54
eISSN - 1869-5868
pISSN - 0021-2148
DOI - 10.1002/ijch.202100086
Subject(s) - chemistry , chiral symmetry breaking , symmetry breaking , chemical physics , crystallization , enantioselective synthesis , chirality (physics) , absolute configuration , dissolution , symmetry (geometry) , cascade , spontaneous symmetry breaking , computational chemistry , stereochemistry , organic chemistry , physics , nambu–jona lasinio model , catalysis , quantum mechanics , chromatography , geometry , mathematics
All biological systems are composed of molecules of a single chirality. Although many different scenarios can lead to chiral symmetry breaking, the transmission of the absolute configuration of one compound to another one remains challenging. We here demonstrate that during crystallization‐induced chiral symmetry breaking by Viedma ripening, a cascade of different and counteracting processes can occur: solid‐solution formation and dissolution inhibition favor symmetry breaking towards the same absolute configuration, while enantioselective growth inhibition favors symmetry breaking towards the opposite absolute configuration. These insights offer a new playground for controlling symmetry breaking processes that are of fundamental and practical importance.