Open AccessExclusion of linkage of Crohn's disease to previously reported regions on chromosomes 12, 7, and 3 in the belgian population indicates genetic heterogeneity
Author(s) -
Vermeire Severine,
Peeters Marc,
Vlietinck Robert,
Parkes Miles,
Satsangi Jack,
Jewell Derek,
Rutgeerts Paul
Publication year - 2000
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1002/ibd.3780060303
Subject(s) - genetic linkage , genetics , linkage (software) , biology , chromosome , population , genetic heterogeneity , genome , crohn's disease , inflammatory bowel disease , disease , odds ratio , medicine , gene , phenotype , pathology , environmental health
Abstract Susceptibility to inflammatory bowel disease (IBD) is significantly determined by genetic factors. Linkage data from genome‐wide searches have identified regions on chromosomes 16, 12, 7, and 3. Our goal was to replicate these four regions in a Belgian population of IBD families. Fifty‐four IBD families were studied (47 with Crohn's disease [CD] and 7 with mixed CD and ulcerative colitis, containing 79 affected sibpairs (68 CD only, 11 mixed) for the regions previously implicated to chromosomes 16,12,7, and 3. In this study, no evidence for linkage was found on any of the four chromosomal regions studied for either the whole IBD dataset or the CD subgroup. The multipoint maximum logarithm of odds scores were less than 0.7 for all four regions. Exclusion mapping could significantly exclude chromosomes 3, 7, and 12. Despite earlier findings, we could significantly exclude linkage of CD with previously reported regions on chromosomes 12, 7, and 3, and could not find evidence for linkage to chromosome 16. It is important to report these findings in light of the genetic heterogeneity of IBD. A genome‐wide search on a larger group of affected siblings is being analyzed to detect other possible susceptibility loci in the Belgian population.