Open AccessBone mineral density in children and young adults with Crohn's disease
Author(s) -
Semeao Edisio J.,
Jawad Abbas F.,
Zemel Babette S.,
Neiswender Kristin M.,
Piccoli David A.,
Stallings Virginia A.
Publication year - 1999
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1002/ibd.3780050304
Subject(s) - medicine , bone mineral , anthropometry , standard score , bone age , young adult , dual energy x ray absorptiometry , dual energy , pediatrics , osteoporosis , machine learning , computer science
Reduced bone mineral density (BMD) has been reported in adults with Crohn's disease (CD). Less is known about abnormal BMD in children and young adults with CD. The aims of this study are to determine the prevalence of low BMD and to evaluate the effect of growth and pubertal development on BMD in children and young adults with CD. One hundred‐nineteen patients with CD underwent dual‐energy X‐ray absorptiometry (DXA) to determine BMD. Anthropometry and pubertal development were measured. Bone age was measured only in patients older than 8 years of age and who had not grown in height during the last year. One hundred‐nineteen patients (72 male, 47 female) were evaluated. Seventy percent of patients had BMD z‐scores ± −1.0 and 32% had z‐scores ± −2.0. Weight and height z‐scores were significantly associated with BMD z‐scores. BMD z‐scores based on bone age and on chronological age were highly correlated, except when the chronological age BMD z‐score was ± −2.0. BMD z‐score was significantly different between males and females for the group (–1.75 ± 1.06 vs. −1.08 ± 1.00), respectively. Children and young adults with CD have a high prevalence of low BMD and routine evaluation by DXA is indicated. In patients with a chronological age‐based BMD z‐score ± −2.0, a bone agebased BMD should be considered.