Open AccessCancer risk in collagenous colitis
Author(s) -
Chan Jean L.,
Tersmette Anne C.,
Offerhaus G. Johan A.,
Gruber Stephen B.,
Bayless Theodore M.,
Giardiello Francis M.
Publication year - 1999
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1002/ibd.3780050107
Subject(s) - medicine , collagenous colitis , colorectal cancer , relative risk , gastroenterology , microscopic colitis , population , inflammatory bowel disease , colitis , cancer , incidence (geometry) , ulcerative colitis , lung cancer , risk factor , cancer registry , confidence interval , disease , physics , environmental health , optics
Collagenous colitis is a recently described form of chronic inflammatory bowel disease. Other inflammatory bowel disorders are associated with increased risk of colorectal and extracolonic malignancies, but this has not been evaluated in collagenous colitis. Colorectal and extracolonic malignancies were identified in 117 patients with collagenous colitis from the Johns Hopkins Registry. The incidence rates of identified tumors, overall incidence rate of tumors, and overall mortality were then compared with general population through person year analysis with adjustment for population. No cases of colorectal cancer were found in collagenous colitis patients during a mean follow‐up period of 7.0 years (range 2–12 years) after the diagnosis of colitis. Two patients developed colorectal cancer prior to the diagnosis of colitis, but no increase in life‐time relative risk of colorectal cancer was found (relative risk 0.52; 95% confidence limits 0.05–1.5). An increased relative risk of lung cancer in women (relative risk 3.7; 95% confidence limits 1.0–9.6; p = 0.048) was noted. The relative risk of overall malignancy and overall mortality was not different than the general population. In collagenous colitis patients the lifetime relative risk of colorectal cancer and the relative risk after the diagnosis of colitis with a mean observation period of 7 years was not increased. An increase in relative risk of lung cancer in women with collagenous colitis argues for further investigation of the role of smoking and other factors in this disorder.