Open AccessSevere bone pain as an adverse effect of cyclosporin therapy for Crohn's disease
Author(s) -
Isaacs Kim L.
Publication year - 1998
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1002/ibd.3780040205
Subject(s) - medicine , discontinuation , refractory (planetary science) , crohn's disease , adverse effect , bone pain , disease , ciclosporin , transplantation , surgery , physics , astrobiology
A case of severe bone pain associated with cyclosporin therapy for Crohn's disease is reported. Severe leg pain developed in a 32‐year‐old man who was receiving cyclosporin for Crohn's disease that was refractory to medical management. Leg pain was related to the dose of cyclosporin, improved with calcium channel blockade, and resolved on discontinuation of cyclosporin. This syndrome has been described in the renal transplantation literature and may be related to vasoconstriction of bone vasculature.