Enhanced Expression of CXCL10 in Inflammatory Bowel Disease | Zendy

Ann Elisabet Østvik | Zendy; Atle van Beelen Granlund | Zendy; Marit Bugge | Zendy; Nadra Nilsen | Zendy; Sverre H. Torp | Zendy; Helge L. Waldum | Zendy; Jan Kristian Damås | Zendy; Terje Espevik | Zendy; Arne K. Sandvik | Zendy

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Enhanced Expression of CXCL10 in Inflammatory Bowel Disease

Author(s) -

Ann Elisabet Østvik,

Atle van Beelen Granlund,

Marit Bugge,

Nadra Nilsen,

Sverre H. Torp,

Helge L. Waldum,

Jan Kristian Damås,

Terje Espevik,

Arne K. Sandvik

Publication year - 2012

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1002/ibd.23034

Subject(s) - cxcl10 , cxcr3 , inflammatory bowel disease , lamina propria , ulcerative colitis , chemokine , immunology , cxcl16 , medicine , biology , pathology , inflammation , chemokine receptor , epithelium , disease

We explored the gene expression in colonic biopsies of active and inactive inflammatory bowel disease (IBD) in an extensive material of ulcerative colitis (UC) and Crohn's disease (CD). The chemokine CXCL10 and its receptor CXCR3 were among the upregulated genes. This study examined the expression of CXCL10 and the mechanisms for its release in patients with UC or CD and in intestinal epithelial cell (IEC) lines.

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