Lineage Targeted MHC-II Transgenic Mice Demonstrate the Role of Dendritic Cells in Bacterial-driven Colitis | Zendy

Lillian MaggioPrice | Zendy; Audrey Seamons | Zendy; Helle BielefeldtOhmann | Zendy; Weiping Zeng | Zendy; Thea Brabb | Zendy; Carol B. Ware | Zendy; Mingzu Lei | Zendy; Robert M. Hershberg | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Lineage Targeted MHC-II Transgenic Mice Demonstrate the Role of Dendritic Cells in Bacterial-driven Colitis

Author(s) -

Lillian MaggioPrice,

Audrey Seamons,

Helle BielefeldtOhmann,

Weiping Zeng,

Thea Brabb,

Carol B. Ware,

Mingzu Lei,

Robert M. Hershberg

Publication year - 2012

Publication title -

inflammatory bowel diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.932

H-Index - 146

eISSN - 1536-4844

pISSN - 1078-0998

DOI - 10.1002/ibd.23000

Subject(s) - colitis , immunology , cd11c , mhc class ii , immune system , biology , cd8 , inflammatory bowel disease , adoptive cell transfer , major histocompatibility complex , t cell , medicine , disease , pathology , phenotype , biochemistry , gene

Inflammatory bowel disease (IBD) pathogenesis involves an inadequately controlled immune reaction to intestinal microbiota, and CD4(+) T cells, dependent on MHC class II (MHC-II) processing and presentation by antigen-presenting cells (APC), play important roles. The role of professional APC (macrophages and dendritic cells [DCs]) and nonprofessional APC (intestinal epithelial cells [IECs]) in microbial-driven intestinal inflammation remains controversial.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research