Open AccessInflammatory bowel disease: A paradigm for the link between coagulation and inflammation
Author(s) -
Yoshida Hideo,
Granger D. Neil
Publication year - 2009
Publication title -
inflammatory bowel diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.932
H-Index - 146
eISSN - 1536-4844
pISSN - 1078-0998
DOI - 10.1002/ibd.20896
Subject(s) - inflammation , medicine , coagulation , pathogenesis , inflammatory bowel disease , immunology , platelet , disease , platelet activation , mechanism (biology) , ulcerative colitis , bioinformatics , pathology , biology , philosophy , epistemology
Inflammatory bowel diseases (IBDs) are associated with platelet activation and an increased risk for thromboembolism. While the mechanisms that underlie the altered platelet function and hypercoagulable state in IBD remain poorly understood, emerging evidence indicates that inflammation and coagulation are interdependent processes that can initiate a vicious cycle wherein each process propagates and intensifies the other. This review addresses the mechanisms that may account for the mutual activation of coagulation and inflammation during inflammation and summarizes evidence that implicates a role for platelets and the coagulation system in the pathogenesis of human and experimental IBD. The proposed link between inflammation and coagulation raises the possibility of targeting the inflammation–coagulation interface to reduce the morbidity and mortality associated with IBD. (Inflamm Bowel Dis 2009)