Premium
Liver zonation, revisited
Author(s) -
Paris Jasmin,
Henderson Neil C.
Publication year - 2022
Publication title -
hepatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.488
H-Index - 361
eISSN - 1527-3350
pISSN - 0270-9139
DOI - 10.1002/hep.32408
Subject(s) - computational biology , transcriptome , biology , lobules of liver , hepatocyte , liver disease , profiling (computer programming) , genomics , bioinformatics , gene , genome , computer science , genetics , gene expression , biochemistry , endocrinology , in vitro , operating system
The concept of hepatocyte functional zonation is well established, with differences in metabolism and xenobiotic processing determined by multiple factors including oxygen and nutrient levels across the hepatic lobule. However, recent advances in single‐cell genomics technologies, including single‐cell and nuclei RNA sequencing, and the rapidly evolving fields of spatial transcriptomic and proteomic profiling have greatly increased our understanding of liver zonation. Here we discuss how these transformative experimental strategies are being leveraged to dissect liver zonation at unprecedented resolution and how this new information should facilitate the emergence of novel precision medicine‐based therapies for patients with liver disease.