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Front Cover: Synthesis of Geminal Bis‐ and Tetrakisphosphonate Ester Derivatives and Their Coordination Behavior Towards Ca(II) Ions (Eur. J. Inorg. Chem. 17/2022)
Author(s) -
Koehne Ingo,
Pietschnig Rudolf
Publication year - 2022
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.202200284
Subject(s) - geminal , chemistry , coordination complex , front cover , calcium , solvent , ion , combinatorial chemistry , stereochemistry , cover (algebra) , organic chemistry , metal , mechanical engineering , engineering
The Front Cover shows an illustration of a hip joint flanked by calcium‐ and phosphorus‐containing capsules, representing the most essential elements of bone tissue. A geminal bisphosphonate (BP) ester‐supported calcium complex forming a solvent‐separated ion pair in the solid state seems to be a convenient and bio‐available combination of these two components. As BPs and derived Ca(II) complexes are the leading class of therapeutics in osteoporosis treatment, the presented results contribute to the availability of differently substituted geminal BPs and Ca(II) compounds for application as potential future multi‐delivery systems in osteoporosis therapy. Additionally, comprehensive X‐ray‐ and DOSY NMR‐based structure elucidation in comparison to structures and coordination motifs known in the literature offers an extended insight into their coordination behavior in the solid as well as in the liquid phase. More information can be found in the Research Article by I. Koehne and R. Pietschnig.