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Cover Feature: Versatile Activity of a Copper(II) Complex Bearing a N 4 ‐Tetradentate Schiff Base Ligand with Reduced Oxygen Species (Eur. J. Inorg. Chem. 8/2022)
Author(s) -
Richezzi Micaela,
Ferreyra Joaquín,
Puzzolo Juan,
Milesi Lisandro,
Palopoli Claudia M.,
Moreno Diego M.,
Hureau Christelle,
Signorella Sandra R.
Publication year - 2022
Publication title -
european journal of inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.667
H-Index - 136
eISSN - 1099-0682
pISSN - 1434-1948
DOI - 10.1002/ejic.202200099
Subject(s) - chemistry , schiff base , ligand (biochemistry) , hydrogen peroxide , redox , adduct , photochemistry , copper , superoxide , polymer chemistry , inorganic chemistry , organic chemistry , enzyme , biochemistry , receptor
The Cover Feature shows the versatility of a copper complex formed with a N 4 ‐tetradentate Schiff‐base ligand: it reacts with hydrogen peroxide and superoxide, and it catalyzes phenol oxidation. The complex scavenges superoxide by employing a Cu(II)/Cu(I) redox cycle for superoxide dismutase activity. In basic medium and at low temperature, it reacts with HO 2 − to form a stable end‐on Cu(II)‐hydroperoxide adduct, which either reacts with a second complex molecule to yield the redox products, through an intermediate peroxo‐bridged dimer (catalase activity), or mediates phenol oxidation, through a ternary transition state (peroxidase activity), under suitable conditions. Kinetic, spectroscopic, and theoretical studies indicate that structural constraints imposed by the ligand distort the coordination geometry of the metal and control reactivity. More information can be found in the Research Article by S. R. Signorella and co‐workers.