Open AccessImpact of SARS‐Cov‐2 infection in patients with hypertrophic cardiomyopathy: results of an international multicentre registry
Author(s) -
Gimeno Juan R.,
Olivotto Iacopo,
Rodríguez Ana Isabel,
Ho Carolyn Y.,
Fernández Adrián,
Quiroga Alejandro,
Espinosa Mari Angeles,
GómezGonzález Cristina,
Robledo María,
TojalSierra Lucas,
Day Sharlene M.,
Owens Anjali,
BarrialesVilla Roberto,
Larrañaga Jose María,
RodríguezPalomares Jose,
GonzálezdelHoyo Maribel,
PiquerasFlores Jesús,
Reza Nosheen,
Chumakova Olga,
Ashley Euan A.,
Parikh Victoria,
Wheeler Matthew,
Jacoby Daniel,
Pereira Alexandre C.,
Saberi Sara,
Helms Adam S.,
Villacorta Eduardo,
GallegoDelgado María,
Castro Daniel,
Domínguez Fernando,
RipollVera Tomás,
ZorioGrima Esther,
SánchezMartínez José Carlos,
GarcíaÁlvarez Ana,
Arbelo Elena,
Mogollón María Victoria,
FuentesCañamero María Eugenia,
Grande Elias,
Peña Carlos,
Monserrat Lorenzo,
Lakdawala Neal K.
Publication year - 2022
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.13964
Subject(s) - medicine , hypertrophic cardiomyopathy , intensive care unit , heart failure , atrial fibrillation , odds ratio , cardiology , cardiomyopathy , confidence interval , stroke (engine) , mechanical engineering , engineering
Aims To describe the natural history of SARS‐CoV‐2 infection in patients with hypertrophic cardiomyopathy (HCM) compared with a control group and to identify predictors of adverse events. Methods and results Three hundred and five patients [age 56.6 ± 16.9 years old, 191 (62.6%) male patients] with HCM and SARS‐Cov‐2 infection were enrolled. The control group consisted of 91 131 infected individuals. Endpoints were (i) SARS‐CoV‐2 related mortality and (ii) severe clinical course [death or intensive care unit (ICU) admission]. New onset of atrial fibrillation, ventricular arrhythmias, shock, stroke, and cardiac arrest were also recorded. Sixty‐nine (22.9%) HCM patients were hospitalized for non‐ICU level care, and 21 (7.0%) required ICU care. Seventeen (5.6%) died: eight (2.6%) of respiratory failure, four (1.3%) of heart failure, two (0.7%) suddenly, and three (1.0%) due to other SARS‐CoV‐2‐related complications. Covariates associated with mortality in the multivariable were age {odds ratio (OR) per 10 year increase 2.25 [95% confidence interval (CI): 1.12–4.51], P = 0.0229}, baseline New York Heart Association class [OR per one‐unit increase 4.01 (95%CI: 1.75–9.20), P = 0.0011], presence of left ventricular outflow tract obstruction [OR 5.59 (95%CI: 1.16–26.92), P = 0.0317], and left ventricular systolic impairment [OR 7.72 (95%CI: 1.20–49.79), P = 0.0316]. Controlling for age and sex and comparing HCM patients with a community‐based SARS‐CoV‐2 cohort, the presence of HCM was associated with a borderline significant increased risk of mortality OR 1.70 (95%CI: 0.98–2.91, P = 0.0600). Conclusions Over one‐fourth of HCM patients infected with SARS‐Cov‐2 required hospitalization, including 6% in an ICU setting. Age and cardiac features related to HCM, including baseline functional class, left ventricular outflow tract obstruction, and systolic impairment, conveyed increased risk of mortality.