Open AccessProtocol for a systematic review and meta‐analysis of experimental models of amyotrophic lateral sclerosis
Author(s) -
Gregory J. M.,
Waldron F. M.,
Soane T.,
Fulton L.,
Leighton D.,
Chataway J.,
Pal S.,
Chandran S.,
Macleod M. R.
Publication year - 2016
Publication title -
evidence‐based preclinical medicine
Language(s) - English
Resource type - Journals
ISSN - 2054-703X
DOI - 10.1002/ebm2.23
Subject(s) - amyotrophic lateral sclerosis , medicine , psychological intervention , disease , protocol (science) , meta analysis , systematic review , induced pluripotent stem cell , neuroscience , medline , psychology , pathology , biology , alternative medicine , psychiatry , biochemistry , embryonic stem cell , gene
Amyotrophic lateral sclerosis ( ALS ) is a rapidly progressive neurodegenerative disease with no cure and limited treatment options. There is therefore an urgent need for effective therapeutic interventions in this disease. This protocol outlines the strategy for a systematic review and meta‐analysis to identify, from in vivo animal and human induced pluripotent stem cell ( hiPSC ) studies, potential therapeutic interventions for ALS . Our aim is to perform a comprehensive review of the ALS literature to compile a list of (1) candidate interventions and (2) target pathways that may be of therapeutic benefit in patients with ALS .