Open AccessProtocol for meta‐analysis of temperature reduction in animal models of cardiac arrest
Author(s) -
Olai H.,
Thornéus G.,
Watson H.,
Macleod M.R.,
Friberg H.,
Rhodes J.,
Nielsen N.,
Cronberg T.,
Deierborg T.
Publication year - 2016
Publication title -
evidence‐based preclinical medicine
Language(s) - English
Resource type - Journals
ISSN - 2054-703X
DOI - 10.1002/ebm2.14
Subject(s) - protocol (science) , targeted temperature management , meta analysis , clinical trial , medicine , intensive care medicine , psychological intervention , outcome (game theory) , psychology , emergency medicine , alternative medicine , resuscitation , cardiopulmonary resuscitation , return of spontaneous circulation , psychiatry , pathology , mathematics , mathematical economics
Targeted temperature management ( TTM ) of 32–34 °C has been the standard treatment for out‐of‐hospital cardiac arrest since clinical trials in 2002 showed benefits to survival and neurological outcome. Recently, this treatment has been challenged by another clinical trial showing no difference in outcome between TTM of 33 °C and 36 °C. This protocol describes the methodology for a meta‐analysis detailing temperature‐reducing interventions to treat global ischaemia in animal models. By combining relevant data sets in the literature, we will explore the experimental evidence for TTM . Our aims are to explain possible translational gaps and provide methodological considerations for future experimental research and clinical trials.