Open AccessSubjective cognitive decline and self‐reported sleep problems: The SCIENCe project
Author(s) -
Exalto Lieza G.,
Hendriksen Heleen M.A.,
Barkhof Frederik,
den Bosch Karlijn A.,
Ebenau Jarith L.,
LeeuwenstijnKoopman Mardou,
Prins Niels D.,
Teunissen Charlotte E.,
Visser Leonie N.C.,
Scheltens Philip,
Flier Wiesje M.
Publication year - 2022
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12287
Subject(s) - pittsburgh sleep quality index , cognition , sleep apnea , anxiety , cohort , medicine , sleep (system call) , obstructive sleep apnea , effects of sleep deprivation on cognitive performance , polysomnography , cognitive decline , clinical psychology , physical therapy , psychiatry , psychology , audiology , apnea , sleep quality , dementia , disease , computer science , operating system
We aim to investigate the frequency and type of sleep problems in memory clinic patients with subjective cognitive decline (SCD) and their association with cognition, mental health, brain magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) biomarkers. Three hundred eight subjects (65 ± 8 years, 44% female) were selected from the Subjective Cognitive Impairment Cohort (SCIENCe) project. All subjects answered two sleep questionnaires, Berlin Questionnaire (sleep apnea) and Pittsburgh Sleep Quality Index (sleep quality) and underwent a standardized memory clinic work‐up. One hundred ninety‐eight (64%) subjects reported sleep problems, based on 107 (35%) positive screenings on sleep apnea and 162 (53%) on poor sleep quality. Subjects with sleep problems reported more severe depressive symptoms, more anxiety, and more severe SCD. Cognitive tests, MRI, and CSF biomarkers did not differ between groups. Our results suggest that improvement of sleep quality and behaviors are potential leads for treatment in many subjects with SCD to relieve the experienced cognitive complaints.