Open AccessPeriodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly
Author(s) -
Kamer Angela R.,
Pushalkar Smruti,
Gulivindala Deepthi,
Butler Tracy,
Li Yi,
Annam Kumar Raghava Chowdary,
Glodzik Lidia,
Ballman Karla V.,
Corby Patricia M.,
Blennow Kaj,
Zetterberg Henrik,
Saxena Deepak,
Leon Mony J.
Publication year - 2021
Publication title -
alzheimer's and dementia: diagnosis, assessment and disease monitoring
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.497
H-Index - 37
ISSN - 2352-8729
DOI - 10.1002/dad2.12172
Subject(s) - dysbiosis , biomarker , cerebrospinal fluid , biology , pathology , bacteria , medicine , microbiology and biotechnology , immunology , disease , genetics
Periodontal disease is a chronic, inflammatory bacterial dysbiosis that is associated with both Alzheimer's disease (AD) and Down syndrome. Methods A total of 48 elderly cognitively normal subjects were evaluated for differences in subgingival periodontal bacteria (assayed by 16S rRNA sequencing) between cerebrospinal fluid (CSF) biomarker groups of amyloid and neurofibrillary pathology. A dysbiotic index (DI) was defined at the genus level as the abundance ratio of known periodontal bacteria to healthy bacteria. Analysis of variance/analysis of covariance (ANOVA/ANCOVA), linear discriminant effect‐size analyses (LEfSe) were used to determine the bacterial genera and species differences between the CSF biomarker groups. Results At genera and species levels, higher subgingival periodontal dysbiosis was associated with reduced CSF amyloid beta (Aβ)42 ( P = 0.02 and 0.01) but not with P‐tau. Discussion We show a selective relationship between periodontal disease bacterial dysbiosis and CSF biomarkers of amyloidosis, but not for tau. Further modeling is needed to establish the direct link between oral bacteria and Aβ.