Recombinant Viral Vectors as Neuroscience Tools | Zendy

Chen ShihHeng | Zendy; Haam Juhee | Zendy; Walker Mitzie | Zendy; Scappini Erica | Zendy; Naughton John | Zendy; Martin Negin P. | Zendy

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Recombinant Viral Vectors as Neuroscience Tools

Author(s) -

Chen ShihHeng,

Haam Juhee,

Walker Mitzie,

Scappini Erica,

Naughton John,

Martin Negin P.

Publication year - 2019

Publication title -

current protocols in neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.307

H-Index - 40

eISSN - 1934-8576

pISSN - 1934-8584

DOI - 10.1002/cpns.67

Subject(s) - tropism , viral vector , recombinant dna , rabies , virology , biology , rabies virus , tissue tropism , neuroscience , gene delivery , computational biology , virus , gene , genetic enhancement , genetics

Recombinant viruses are highly efficient vehicles for in vivo gene delivery. Viral vectors expand the neurobiology toolbox to include direct and rapid anterograde, retrograde, and trans‐synaptic delivery of tracers, sensors, and actuators to the mammalian brain. Each viral type offers unique advantages and limitations. To establish strategies for selecting a suitable viral type, this article aims to provide readers with an overview of viral recombinant technology, viral structure, tropism, and differences between serotypes and pseudotypes for three of the most commonly used vectors in neurobiology research: adeno‐associated viruses, retro/lentiviruses, and glycoprotein‐deleted rabies viruses. © 2019 by John Wiley & Sons, Inc.

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