Using LICHeE and BAMSE for Reconstructing Cancer Phylogenetic Trees | Zendy

Ricketts Camir | Zendy; Popic Victoria | Zendy; Toosi Hosein | Zendy; Hajirasouliha Iman | Zendy

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Using LICHeE and BAMSE for Reconstructing Cancer Phylogenetic Trees

Author(s) -

Ricketts Camir,

Popic Victoria,

Toosi Hosein,

Hajirasouliha Iman

Publication year - 2018

Publication title -

current protocols in bioinformatics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.535

H-Index - 57

eISSN - 1934-340X

pISSN - 1934-3396

DOI - 10.1002/cpbi.49

Subject(s) - phylogenetic tree , phylogenetics , evolutionary biology , biology , tree (set theory) , computational biology , computer science , genealogy , genetics , mathematics , combinatorics , gene , history

The reconstruction of cancer phylogeny trees and quantifying the evolution of the disease is a challenging task. LICHeE and BAMSE are two computational tools designed and implemented recently for this purpose. They both utilize estimated variant allele fraction of somatic mutations across multiple samples to infer the most likely cancer phylogenies. This unit provides extensive guidelines for installing and running both LICHeE and BAMSE. © 2018 by John Wiley & Sons, Inc.

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