Open AccessSemipermeable hollow fiber phantoms for development and validation of perfusion‐sensitive mr methods and signal models
Author(s) -
Anderson J.R.,
Ackerman J.J.H.,
Garbow J.R.
Publication year - 2011
Publication title -
concepts in magnetic resonance part b: magnetic resonance engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 32
eISSN - 1552-504X
pISSN - 1552-5031
DOI - 10.1002/cmr.b.20202
Subject(s) - semipermeable membrane , biomedical engineering , fiber , capillary action , imaging phantom , hollow fiber membrane , signal (programming language) , materials science , perfusion , lumen (anatomy) , peristaltic pump , chemistry , membrane , composite material , computer science , nuclear medicine , radiology , medicine , surgery , biochemistry , physics , meteorology , programming language
Two semipermeable, hollow fiber phantoms for the validation of perfusion‐sensitive magnetic resonance methods and signal models are described. Semipermeable hollow fibers harvested from a standard commercial hemodialysis cartridge serve to mimic tissue capillary function. Flow of aqueous media through the fiber lumen is achieved with a laboratory‐grade peristaltic pump. Diffusion of water and solute species (e.g., Gd‐based contrast agent) occurs across the fiber wall, allowing exchange between the lumen and the extralumenal space. Phantom design attributes include: i) small physical size, ii) easy and low‐cost construction, iii) definable compartment volumes, and iv) experimental control over media content and flow rate. © 2011 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 39B: 149–158, 2011