Open AccessHR‐MAS NMR spectroscopy in the characterization of human tissues: Application to healthy gastric mucosa
Author(s) -
Schenetti Luisa,
Mucci Adele,
Parenti Francesca,
Cagnoli Rita,
Righi Valeria,
Tosi M. Raffaella,
Tugnoli Vitaliano
Publication year - 2006
Publication title -
concepts in magnetic resonance part a
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.229
H-Index - 49
eISSN - 1552-5023
pISSN - 1546-6086
DOI - 10.1002/cmr.a.20068
Subject(s) - spectroscopy , characterization (materials science) , resolution (logic) , gastric mucosa , nuclear magnetic resonance spectroscopy , chemistry , high resolution , analytical chemistry (journal) , spectral line , nuclear magnetic resonance , materials science , chromatography , computer science , nanotechnology , stereochemistry , biochemistry , stomach , physics , artificial intelligence , remote sensing , quantum mechanics , geology , astronomy
The HR‐MAS is an ideal technique for the investigation of intact tissue specimens (10–50 mg) and permits the obtainment of spectra with a resolution comparable to that observed in solution in a time that does not exceed a half of an hour for a routine analysis. The potentialities of HR‐MAS NMR spectroscopy in the identification of the metabolites characterizing the healthy gastric mucosa are here presented. The direct inspection of the 1D 1 H NMR spectra enables only few metabolites to be confidently assigned, and the use of selected 2D experiments strongly amplify the analytical effectiveness of the technique. © 2006 Wiley Periodicals, Inc. Concepts Magn Reson Part A 28A: 430–443, 2006
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