Hyperpolarized  6 Li as a probe for hemoglobin oxygenation level | Zendy

Balzan Riccardo | Zendy; Mishkovsky Mor | Zendy; Simonenko Yana | Zendy; Heeswijk Ruud B. | Zendy; Gruetter Rolf | Zendy; Eliav Uzi | Zendy; Navon Gil | Zendy; Comment Arnaud | Zendy

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Hyperpolarized 6 Li as a probe for hemoglobin oxygenation level

Author(s) -

Balzan Riccardo,

Mishkovsky Mor,

Simonenko Yana,

Heeswijk Ruud B.,

Gruetter Rolf,

Eliav Uzi,

Navon Gil,

Comment Arnaud

Publication year - 2015

Publication title -

contrast media & molecular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.714

H-Index - 50

eISSN - 1555-4317

pISSN - 1555-4309

DOI - 10.1002/cmmi.1656

Subject(s) - hyperpolarization (physics) , paramagnetism , ion , chemistry , spins , nuclear magnetic resonance , relaxation (psychology) , dissolution , aqueous solution , polarization (electrochemistry) , lithium (medication) , analytical chemistry (journal) , nuclear magnetic resonance spectroscopy , physics , condensed matter physics , medicine , psychology , social psychology , organic chemistry , chromatography , endocrinology

Hyperpolarization by dissolution dynamic nuclear polarization (DNP) is a versatile technique to dramatically enhance the nuclear magnetic resonance (NMR) signal intensity of insensitive long‐ T 1 nuclear spins such as 6 Li. The 6 Li longitudinal relaxation of lithium ions in aqueous solutions strongly depends on the concentration of paramagnetic species, even if they are present in minute amounts. We herein demonstrate that blood oxygenation can be readily detected by taking advantage of the 6 Li signal enhancement provided by dissolution DNP, together with the more than 10% decrease in 6 Li longitudinal relaxation as a consequence of the presence of paramagnetic deoxyhemoglobin. Copyright © 2015 John Wiley & Sons, Ltd.

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