Multifunctional theranostic gold nanoparticles for targeted CT imaging and photothermal therapy
Author(s) -
Curry Taeyjuana,
Kopelman Raoul,
Shilo Malka,
Popovtzer Rachela
Publication year - 2014
Publication title -
contrast media & molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.714
H-Index - 50
eISSN - 1555-4317
pISSN - 1555-4309
DOI - 10.1002/cmmi.1563
Subject(s) - photothermal therapy , colloidal gold , nanotechnology , nanoparticle , medicine , gold standard (test) , computed tomography , medical physics , biomedical engineering , materials science , radiology
Gold nanoparticles have emerged as some of the most extensively utilized nanoplatforms for the diagnosis, imaging, monitoring and treatment of malignant diseases. In particular, in computed tomography (CT) imaging and in therapy (PTT), the exploitation of the various, advantageous properties of gold nanoparticles have resulted in numerous advances in each of these fields. The purpose of this review is to assess the status of gold‐nanoparticle mediated CT and PTT, highlight several promising outcomes and motivate the combination of these two functionalities in the same nanoparticle platform. The given examples of research based advances and the encouraging results of in vitro and in vivo studies provide much excitement and promise for future theranostic (therapy + diagnostic) clinical applications, as well as for image‐guided therapy and/or surgery, and their monitoring. Copyright © 2014 John Wiley & Sons, Ltd.
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