Open AccessComparison of dynamic contrast‐enhanced MRI and quantitative SPECT in a rat glioma model
Author(s) -
Skinner Jack T.,
Yankeelov Thomas E.,
Peterson Todd E.,
Does Mark D.
Publication year - 2012
Publication title -
contrast media & molecular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.714
H-Index - 50
eISSN - 1555-4317
pISSN - 1555-4309
DOI - 10.1002/cmmi.1479
Subject(s) - dynamic contrast enhanced mri , perfusion , contrast (vision) , glioma , nuclear medicine , dynamic contrast , chemistry , biomedical engineering , magnetic resonance imaging , computer science , medicine , radiology , artificial intelligence , cancer research
Pharmacokinetic modeling of dynamic contrast‐enhanced (DCE) MRI data provides measures of the extracellular‐extravascular volume fraction ( v e ) and the volume transfer constant ( K trans ) in a given tissue. These parameter estimates may be biased, however, by confounding issues such as contrast agent and tissue water dynamics, or assumptions of vascularization and perfusion made by the commonly used model. In contrast to MRI, radiotracer imaging with SPECT is insensitive to water dynamics. A quantitative dual‐isotope SPECT technique was developed to obtain an estimate of v e in a rat glioma model for comparison with the corresponding estimates obtained using DCE‐MRI with a vascular input function and reference region model. Both DCE‐MRI methods produced consistently larger estimates of v e in comparison to the SPECT estimates, and several experimental sources were postulated to contribute to these differences. Copyright © 2012 John Wiley & Sons, Ltd.