Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI  T  2  contrast agent with tunable proton relaxivities | Zendy

Ye Fei | Zendy; Laurent Sophie | Zendy; Fornara Andrea | Zendy; Astolfi Laura | Zendy; Qin Jian | Zendy; Roch Alain | Zendy; Martini Alessandro | Zendy; Toprak Muhammet S. | Zendy; Muller Robert N. | Zendy; Muhammed Mamoun | Zendy

Open Access

Uniform mesoporous silica coated iron oxide nanoparticles as a highly efficient, nontoxic MRI T 2 contrast agent with tunable proton relaxivities

Author(s) -

Ye Fei,

Laurent Sophie,

Fornara Andrea,

Astolfi Laura,

Qin Jian,

Roch Alain,

Martini Alessandro,

Toprak Muhammet S.,

Muller Robert N.,

Muhammed Mamoun

Publication year - 2012

Publication title -

contrast media & molecular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.714

H-Index - 50

eISSN - 1555-4317

pISSN - 1555-4309

DOI - 10.1002/cmmi.1473

Subject(s) - coating , biocompatibility , nanoparticle , mesoporous material , materials science , mesoporous silica , relaxometry , superparamagnetism , mri contrast agent , dispersity , nuclear magnetic resonance , chemical engineering , magnetic resonance imaging , nanotechnology , chemistry , magnetization , organic chemistry , polymer chemistry , catalysis , metallurgy , magnetic field , medicine , physics , spin echo , quantum mechanics , engineering , radiology

Monodisperse mesoporous silica (mSiO 2 ) coated superparamagnetic iron oxide (Fe 3 O 4 @mSiO 2 ) nanoparticles (NPs) have been developed as a potential magnetic resonance imaging (MRI) T 2 contrast agent. To evaluate the effect of surface coating on MRI contrast efficiency, we examined the proton relaxivities of Fe 3 O 4 @mSiO 2 NPs with different coating thicknesses. It was found that the mSiO 2 coating has a significant impact on the efficiency of Fe 3 O 4 NPs for MRI contrast enhancement. The efficiency increases with the thickness of mSiO 2 coating and is much higher than that of the commercial contrast agents. Nuclear magnetic resonance (NMR) relaxometry of Fe 3 O 4 @mSiO 2 further revealed that mSiO 2 coating is partially permeable to water molecules and therefore induces the decrease of longitudinal relaxivity, r 1 . Biocompatibility evaluation of various sized (ca. 35–95 nm) Fe 3 O 4 @mSiO 2 NPs was tested on OC‐k3 cells and the result showed that these particles have no negative impact on cell viability. The enhanced MRI efficiency of Fe 3 O 4 @mSiO 2 highlights these core–shell particles as highly efficient T 2 contrast agents with high biocompatibility. Copyright © 2012 John Wiley & Sons, Ltd.

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