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Conception and Evaluation of Fluorescent Phosphine‐Gold Complexes: From Synthesis to in vivo Investigations
Author(s) -
Rousselle Benjamin,
Massot Aurélie,
Privat Malorie,
Dondaine Lucile,
Trommenschlager Audrey,
Bouyer Florence,
Bayardon Jérôme,
Ghiringhelli François,
Bettaieb Ali,
Goze Christine,
Paul Catherine,
MalaceaKabbara Raluca,
Bodio Ewen
Publication year - 2022
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.202100773
Subject(s) - in vivo , fluorescence , phosphonium , phosphine , chemistry , moiety , in vitro , quantum yield , coumarin , absorption (acoustics) , biophysics , combinatorial chemistry , photochemistry , stereochemistry , materials science , biochemistry , organic chemistry , biology , physics , microbiology and biotechnology , quantum mechanics , composite material , catalysis
A phosphine gold(I) and phosphine‐phosphonium gold(I) complexes bearing a fluorescent coumarin moiety were synthesized and characterized. Both complexes displayed interesting photophysical properties: good molar absorption coefficient, good quantum yield of fluorescence, and ability to be tracked in vitro thanks to two‐photon imaging. Their in vitro and in vivo biological properties were evaluated onto cancer cell lines both human and murine and into CT26 tumor‐bearing BALB/c mice. They displayed moderate to strong antiproliferative properties and the phosphine‐phosphonium gold(I) complex induced significant in vivo anti‐cancer effect.