Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts | Zendy

Nagayama Masafumi | Zendy; Haga Hisashi | Zendy; Kawabata Kazushige | Zendy

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Drastic change of local stiffness distribution correlating to cell migration in living fibroblasts

Author(s) -

Nagayama Masafumi,

Haga Hisashi,

Kawabata Kazushige

Publication year - 2001

Publication title -

cell motility and the cytoskeleton

Language(s) - English

Resource type - Journals

eISSN - 1097-0169

pISSN - 0886-1544

DOI - 10.1002/cm.10008

Subject(s) - stiffness , cytoskeleton , biology , cell migration , cell , distribution (mathematics) , microbiology and biotechnology , biophysics , materials science , biochemistry , composite material , mathematical analysis , mathematics

Sequential images of the local stiffness distribution of living fibroblasts (NIH3T3) were captured under a culture condition using scanning probe microscopy in a force modulation mode. We found a clear relation between cell migration and local stiffness distribution on the cell: When cells were stationary at one position, the stiffness distribution of their cellular surface was quite stable. On the other hand, once the cells started to move, the stiffness in their nuclear regions drastically decreased. Possible explanations for the correlation between the cell migration and the cell stiffness are proposed. Cell Motil. Cytoskeleton 50:173–179, 2001. © 2001 Wiley‐Liss, Inc.

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