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A recent update on new synthetic chiral compounds with antileishmanial activity
Author(s) -
Verboni Michele,
Olivieri Diego,
Lucarini Simone
Publication year - 2022
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23494
Subject(s) - enantiopure drug , leishmaniasis , chirality (physics) , chemistry , enantiomer , malaria , antiparasitic agent , drug discovery , leishmania , antiparasitic , neglected tropical diseases , protozoa , combinatorial chemistry , pharmacology , computational biology , stereochemistry , disease , enantioselective synthesis , immunology , medicine , biochemistry , computer science , biology , microbiology and biotechnology , parasite hosting , chiral symmetry breaking , pathology , world wide web , quark , quantum mechanics , nambu–jona lasinio model , catalysis , physics
Parasitic diseases, including malaria, leishmaniasis, and trypanosomiasis, affect billions of people and are responsible for almost 500,000 deaths/year. In particular, leishmaniasis, a neglected tropical disease, is considered a global public health problem because current drugs have several drawbacks including to toxicity, high cost, and drug resistance, which result in a lack of effective and readily available therapies. Therefore, the synthesis of new, safe, and effective molecules still requires the attention of the scientific community. Moreover, it is well known that chirality plays a crucial role in the antiparasitic activity of molecules, driving the design of their synthesis. Therefore, in this review we report a recent update on new chiral compounds with promising antileishmanial activity, focusing on synthetic approaches. Where reported, in most cases the enantiopure compound has shown better potency against the protozoa than its enantiomer or corresponding racemic mixture.