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Multiscale conformational dynamics probed by time‐resolved circular dichroism from seconds to picoseconds
Author(s) -
Hache François,
Changenet Pascale
Publication year - 2021
Publication title -
chirality
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 77
eISSN - 1520-636X
pISSN - 0899-0042
DOI - 10.1002/chir.23359
Subject(s) - picosecond , nanosecond , chemistry , circular dichroism , folding (dsp implementation) , vibrational circular dichroism , chemical physics , molecular dynamics , molecule , time domain , dynamics (music) , protein folding , crystallography , optics , computational chemistry , physics , laser , biochemistry , electrical engineering , organic chemistry , computer science , acoustics , computer vision , engineering
Time‐resolved circular dichroism has been developed for a few decades to investigate rapid conformational changes in (bio)molecules. In our group, we have come up with several experimental set‐ups allowing us to study pico‐nanosecond local phenomena in molecular systems as well as much slower effects occurring in proteins and DNA in the folding processes. After an overview of the worldwide realizations in this domain, we present emblematic experiments that we have carried out, spanning time domain from picoseconds to seconds.