Open AccessChemInform Abstract: Aerobic Pd‐Catalyzed sp 3 C—H Olefination: A Route to Both N‐Heterocyclic Scaffolds and Alkenes.
Author(s) -
Stowers Kara J.,
Fortner Kevin C.,
Sanford Melanie S.
Publication year - 2011
Publication title -
cheminform
Language(s) - English
Resource type - Journals
eISSN - 1522-2667
pISSN - 0931-7597
DOI - 10.1002/chin.201137155
Subject(s) - chemistry , catalysis , organic chemistry , nitrogen , combinatorial chemistry , radical cyclization , medicinal chemistry
The Pd‐catalyzed olefination and cyclization of various 2‐alkylpyridines and α,β‐unsaturated alkenes utilizes air as the terminal oxidant and provides a conceptually novel entry to 6,5‐nitrogen heterocycles, which constitute the cores of numerous alkaloid natural products.
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