Study of Carbamoyl Fluoride: Synthesis, Properties and Applications | Zendy

Bonnefoy Clémence | Zendy; Chefdeville Emmanuel | Zendy; Tourvieille Christian | Zendy; Panossian Armen | Zendy; Hanquet Gilles | Zendy; Leroux Frédéric | Zendy; Toulgoat Fabien | Zendy; Billard Thierry | Zendy

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Study of Carbamoyl Fluoride: Synthesis, Properties and Applications

Author(s) -

Bonnefoy Clémence,

Chefdeville Emmanuel,

Tourvieille Christian,

Panossian Armen,

Hanquet Gilles,

Leroux Frédéric,

Toulgoat Fabien,

Billard Thierry

Publication year - 2022

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.202201589

Subject(s) - fluoride , lipophilicity , chemistry , combinatorial chemistry , radiochemistry , organic chemistry , inorganic chemistry

Carbamoyl fluoride is a fluorinated group that, to this date, remains underexplored, probably due to the lack of data concerning its properties. In this paper, a study of carbamoyl fluoride is presented. Stability studies, in particular under physiological conditions, and lipophilicity measurement were performed. A new easy, safe, inexpensive, and metal‐free synthesis method is also described. Finally, a potential use in radiochemistry through a 18 F/ 19 F isotopic exchange is demonstrated.

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