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Study of Carbamoyl Fluoride: Synthesis, Properties and Applications
Author(s) -
Bonnefoy Clémence,
Chefdeville Emmanuel,
Tourvieille Christian,
Panossian Armen,
Hanquet Gilles,
Leroux Frédéric,
Toulgoat Fabien,
Billard Thierry
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202201589
Subject(s) - fluoride , lipophilicity , chemistry , combinatorial chemistry , radiochemistry , organic chemistry , inorganic chemistry
Carbamoyl fluoride is a fluorinated group that, to this date, remains underexplored, probably due to the lack of data concerning its properties. In this paper, a study of carbamoyl fluoride is presented. Stability studies, in particular under physiological conditions, and lipophilicity measurement were performed. A new easy, safe, inexpensive, and metal‐free synthesis method is also described. Finally, a potential use in radiochemistry through a 18 F/ 19 F isotopic exchange is demonstrated.