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Copper‐Catalyzed Direct Perfluoroalkylation of Heteroarenes
Author(s) -
Baguia Hajar,
Evano Gwilherm
Publication year - 2022
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202103599
Subject(s) - furan , iodide , chemistry , copper , catalysis , combinatorial chemistry , regioselectivity , organic chemistry
An efficient and broadly applicable process is reported for the copper‐catalyzed direct perfluoroalkylation of C−H bonds in heteroarenes with commercially available perfluoroalkyl iodides. This reaction is based on a simple combination of copper(I) iodide and 1,10‐phenanthroline enabling the easy reduction of perfluoroalkyl iodides to the corresponding radical species that add to a wide range of heteroarenes including benzofurans, benzothiophenes, (aza)indoles, furans and pyrroles. High levels of regioselectivity were obtained in all cases and the efficiency and robustness of this process was highlighted by the direct perfluoroalkylation of furan‐containing peptides.