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Host‐Guest Systems on the Surface of Functionalized Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Utilizing Hamilton Receptors and Cyanurate Derivative Molecules
Author(s) -
Ali Muhammad,
Kataev Evgeny,
Müller Johannes,
Park Hyoungwon,
Halik Marcus,
Hirsch Andreas
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202102581
Subject(s) - surface modification , supramolecular chemistry , molecule , nanomaterials , titration , hydrogen bond , nanoparticle , monolayer , nanotechnology , molecular recognition , combinatorial chemistry , materials science , chemistry , drug delivery , oxide , chemical engineering , organic chemistry , engineering
The study of hydrogen bonding interactions at the level of functionalized nanoparticles remains highly challenging and poorly explored area. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) were orthogonally functionalized using receptors bearing multiple hydrogen bonding motifs. Pristine SPIONs were modified by wet chemical processes with Hamilton receptors (hosts), or cyanurate‐guest molecules linked to phosphonic acid moieties for monolayer functionalization. The modified surfaces were fully characterized and the number of attached ligands on the surface were determined. The host‐guest interactions on the interface of modified SPIONs were investigated by using UV‐Vis spectroscopic titrations. Functionalized SPIONs demonstrated two to three magnitudes stronger binding affinities as compared to the related molecular interactions in solution due to synergistic effects on complex surface environment. Higher supramolecular binding ratios of host‐guest interactions on the modified surface were emerged. These studies provide fundamental insights into supramolecular complexations on the surface at solid‐liquid interface systems with applications in engineered nanomaterials, nano‐sensing devices, and drug delivery systems.