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Amine‐Directed Palladium‐Catalyzed C−H Halogenation of Phenylalanine Derivatives
Author(s) -
Ville Alexia,
Annibaletto Julien,
Coufourier Sébastien,
Hoarau Christophe,
Tamion Rodolphe,
Journot Guillaume,
Schneider Cédric,
Brière JeanFrançois
Publication year - 2021
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.202102411
Subject(s) - halogenation , palladium , trifluoroacetic acid , phenylalanine , chemistry , amine gas treating , catalysis , amino acid , organic chemistry , combinatorial chemistry , biochemistry
An efficient primary‐amine‐directed, palladium‐catalyzed C−H halogenation (X=I, Br, Cl) of phenylalanine derivatives is reported on a range of quaternary amino acid (AA) derivatives thanks to suitable conditions employing trifluoroacetic acid as additive. The extension of this original native functionality‐directed ortho ‐selective halogenation was even demonstrated with the more challenging native phenylalanine as tertiary AA.