Open AccessIn silico analysis for transcription factors with Zn(II) 2 C 6 binuclear cluster DNA‐binding domains in Candida albicans
Author(s) -
Maicas Sergi,
Moreno Inmaculada,
Nieto Almudena,
Gómez Micaela,
Sentandreu Rafael,
Valentín Eulogio
Publication year - 2005
Publication title -
comparative and functional genomics
Language(s) - English
Resource type - Journals
eISSN - 1532-6268
pISSN - 1531-6912
DOI - 10.1002/cfg.492
Subject(s) - computer science , in silico , data mining , biology , gene , genetics
A total of 6047 open reading frames in the Candida albicans genome were screened for Zn(II) 2 C 6 ‐type zinc cluster proteins (or binuclear cluster proteins) involved in DNA recognition. These fungal proteins are transcription regulators of genes involved in a wide range of cellular processes, including metabolism of different compounds such as sugars or amino acids, as well as multi‐drug resistance, control of meiosis, cell wall architecture, etc. The selection criteria used in the sequence analysis were the presence of the CysX 2 CysX 6 CysX 5–16 CysX 2 CysX 6–8 Cys motif and a putative nuclear localization signal. Using this approach, 70 putative Zn(II) 2 C 6 transcription factors have been found in the genome of C. albicans . Copyright © 2005 John Wiley & Sons, Ltd.