Open AccessOntology for genome comparison and genomic rearrangements
Author(s) -
Flanagan Keith,
Stevens Robert,
Pocock Matthew,
Lee Pete,
Wipat Anil
Publication year - 2004
Publication title -
comparative and functional genomics
Language(s) - English
Resource type - Journals
eISSN - 1532-6268
pISSN - 1531-6912
DOI - 10.1002/cfg.436
Subject(s) - ontology , computer science , genome , annotation , ontology based data integration , process ontology , genomics , comparative genomics , human genome , data science , information retrieval , biology , artificial intelligence , genetics , gene , semantic web , philosophy , epistemology
We present an ontology for describing genomes, genome comparisons, their evolution and biological function. This ontology will support the development of novel genome comparison algorithms and aid the community in discussing genomic evolution. It provides a framework for communication about comparative genomics, and a basis upon which further automated analysis can be built. The nomenclature defined by the ontology will foster clearer communication between biologists, and also standardize terms used by data publishers in the results of analysis programs. The overriding aim of this ontology is the facilitation of consistent annotation of genomes through computational methods, rather than human annotators. To this end, the ontology includes definitions that support computer analysis and automated transfer of annotations between genomes, rather than relying upon human mediation. Copyright © 2004 John Wiley & Sons, Ltd.