Open AccessLooking for cancer clues in publicly accessible databases
Author(s) -
Medjahed Djamel,
Lemkin Peter F.,
Smythers Gary W.,
Munroe David J.
Publication year - 2004
Publication title -
comparative and functional genomics
Language(s) - English
Resource type - Journals
eISSN - 1532-6268
pISSN - 1531-6912
DOI - 10.1002/cfg.378
Subject(s) - cancer , computer science , proteomics , knowledge base , database , computational biology , world wide web , data science , information retrieval , bioinformatics , biology , gene , genetics
What started out as a mere attempt to tentatively identify proteins in experimental cancer‐related 2D‐PAGE maps developed into VIRTUAL2D, a web‐accessible repository for theoretical pI/MW charts for 92 organisms. Using publicly available expression data, we developed a collection of tissue‐specific plots based on differential gene expression between normal and diseased states. We use this comparative cancer proteomics knowledge base, known as the tissue molecular anatomy project (TMAP), to uncover threads of cancer markers common to several types of cancer and to relate this information to established biological pathways. Copyright © 2004 John Wiley & Sons, Ltd.