Open AccessUse of complex DNA and antibody microarrays as tools in functional analyses
Author(s) -
Bauer Andrea,
Beckmann Boris,
Busold Christian,
Brandt Ole,
Kusnezow Wlad,
Pullat Janne,
Aign Verena,
Fellenberg Kurt,
Fleischer Robert,
Jacob Anette,
Frohme Marcus,
Hoheisel Jörg D.
Publication year - 2003
Publication title -
comparative and functional genomics
Language(s) - English
Resource type - Journals
eISSN - 1532-6268
pISSN - 1531-6912
DOI - 10.1002/cfg.320
Subject(s) - dna microarray , computational biology , biology , computer science , dna sequencing , data science , dna , genetics , gene , gene expression
Abstract While the deciphering of basic sequence information on a genomic scale is yielding complete genomic sequences in ever‐shorter intervals, experimental procedures for elucidating the cellular effects and consequences of the DNA‐encoded information become critical for further analyses. In recent years, DNA microarray technology has emerged as a prime candidate for the performance of many such functional assays. Technically, array technology has come a long way since its conception some 15 years ago, initially designed as a means for large‐scale mapping and sequencing. The basic arrangement, however, could be adapted readily to serve eventually as an analytical tool in a large variety of applications. On their own or in combination with other methods, microarrays open up many new avenues of functional analysis. Copyright © 2003 John Wiley & Sons, Ltd.